The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells.

The clinical use of all-trans-retinoic acid (ATRA) in the treatment of cancer is significantly hampered by the prompt emergence of resistance, believed to be caused by increased ATRA catabolism. Inhibitors of ATRA catabolism may therefore prove valuable for cancer therapy. Liarozole-fumarate is an a...

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Bibliografische gegevens
Hoofdauteurs: Van heusden, J., Wouters, W., Ramaekers, F. C., Krekels, M. D., Dillen, L., Borgers, M., Smets, G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 1998
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150171/
https://ncbi.nlm.nih.gov/pubmed/9579827
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