The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells.

The clinical use of all-trans-retinoic acid (ATRA) in the treatment of cancer is significantly hampered by the prompt emergence of resistance, believed to be caused by increased ATRA catabolism. Inhibitors of ATRA catabolism may therefore prove valuable for cancer therapy. Liarozole-fumarate is an a...

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Main Authors: Van heusden, J., Wouters, W., Ramaekers, F. C., Krekels, M. D., Dillen, L., Borgers, M., Smets, G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1998
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150171/
https://ncbi.nlm.nih.gov/pubmed/9579827
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