Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.

Pulse radiolysis was used to generate radicals from one electron reduction of 1,2,4-benzotriazine-1,4-dioxides (derivatives of tirapazamine), and of imidazo [1,2-a]quinoxaline-4-oxides (analogues of RB90740), which have selective toxicity towards hypoxic cells. Radicals from the mono N-oxides (from...

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Main Authors: Wardman, P., Priyadarsini, K. I., Dennis, M. F., Everett, S. A., Naylor, M. A., Patel, K. B., Stratford, I. J., Stratford, M. R., Tracy, M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150009/
https://ncbi.nlm.nih.gov/pubmed/8763850
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