Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells.

To investigate the role of beta-tubulin isotype composition in resistance to paclitaxel, an anti-microtubule agent, human prostate carcinoma (DU-145) cells were intermittently exposed to increasing concentrations of paclitaxel. Cells that were selected and maintained at 10 nM paclitaxel (Pac-10) wer...

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Main Authors: Ranganathan, S., Benetatos, C. A., Colarusso, P. J., Dexter, D. W., Hudes, G. R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149944/
https://ncbi.nlm.nih.gov/pubmed/9484812
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