Nitropyrrole radiosensitizers: structure function relationships.

Nitropyrrole derivatives have been tested as hypoxic cell radiosensitizers in vitro and in vivo. Radiosensitizing potential generally increases with nitropyrrole electron affinity. N-hydroxyethyl substitution decreases toxicity relative to N--CH3, N--CH2 CH3 and N--CH2 CH2 CH3 substitution. The most...

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Bibliografische gegevens
Hoofdauteurs: Raleigh, J. A., Chapman, J. D., Reuvers, A. P., Biaglow, J. E., Durand, R. E., Rauth, A. M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 1978
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149400/
https://ncbi.nlm.nih.gov/pubmed/277259
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