Mode of Action of Interleukin-6 on Mature Osteoclasts. Novel Interactions with Extracellular Ca(2+) Sensing in the Regulation of Osteoclastic Bone Resorption

We describe a physiologically significant mechanism through which interleukin-6 (IL-6) and a rising ambient Ca(2+) interact to regulate osteoclastic bone resorption. VOXEL-based confocal microscopy of nonpermeabilized osteoclasts incubated with anti– IL-6 receptor antibodies revealed intense, strict...

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Bibliographic Details
Main Authors: Adebanjo, Olugbenga A., Moonga, Baljit S., Yamate, Tomoo, Sun, Li, Minkin, Cedric, Abe, Etsuko, Zaidi, Mone
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149353/
https://ncbi.nlm.nih.gov/pubmed/9732294
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