The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel

The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovaria...

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Hauptverfasser: Ahmed, Ahmed Ashour, Mills, Anthony D., Ibrahim, Ashraf E.K., Temple, Jillian, Blenkiron, Cherie, Vias, Maria, Massie, Charlie E., Iyer, N. Gopalakrishna, McGeoch, Adam, Crawford, Robin, Nicke, Barbara, Downward, Julian, Swanton, Charles, Bell, Stephen D., Earl, Helena M., Laskey, Ronald A., Caldas, Carlos, Brenton, James D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148463/
https://ncbi.nlm.nih.gov/pubmed/18068629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.11.014
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