Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation of specific leptin receptors (OB-R) in the hypoth...

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Auteurs principaux: Couturier, Cyril, Sarkis, Chamsy, Séron, Karin, Belouzard, Sandrine, Chen, Patty, Lenain, Aude, Corset, Laetitia, Dam, Julie, Vauthier, Virginie, Dubart, Anne, Mallet, Jacques, Froguel, Philippe, Rouillé, Yves, Jockers, Ralf
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148314/
https://ncbi.nlm.nih.gov/pubmed/18042720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706671104
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