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Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes
Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the first large-scale mapping of neuronal MeCP2-binding sites on 26.3 Mb of imprinted and nonimprinted loci revealed that 59% of MeCP2-binding s...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148304/ https://ncbi.nlm.nih.gov/pubmed/18042715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707442104 |
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