Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the first large-scale mapping of neuronal MeCP2-binding sites on 26.3 Mb of imprinted and nonimprinted loci revealed that 59% of MeCP2-binding s...

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Detalhes bibliográficos
Main Authors: Yasui, Dag H., Peddada, Sailaja, Bieda, Mark C., Vallero, Roxanne O., Hogart, Amber, Nagarajan, Raman P., Thatcher, Karen N., Farnham, Peggy J., LaSalle, Janine M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148304/
https://ncbi.nlm.nih.gov/pubmed/18042715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707442104
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