Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia

IGFBP-1 is elevated in fetuses with long-term, chronic hypoxia and intrauterine growth restriction. We investigated the hypothesis that hypoxia regulates IGFBP-1 in the human fetus in vivo and IGFBP-1 gene expression and protein in vitro. Umbilical artery IGFBP-1 levels (mean ± SEM) from term babies...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tazuke, Salli I., Mazure, Natalie M., Sugawara, Junichi, Carland, Grace, Faessen, Gerry H., Suen, Lii-Feng, Irwin, Juan C., Powell, David R., Giaccia, Amato J., Giudice, Linda C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21483/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.10188
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