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Significance Thresholds for Quantitative Trait Locus Mapping Under Selective Genotyping

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with ph...

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Detalles Bibliográficos
Main Authors: Manichaikul, Ani, Palmer, Abraham A., Sen, Śaunak, Broman, Karl W.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147971/
https://ncbi.nlm.nih.gov/pubmed/17720902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.080093
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