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Significance Thresholds for Quantitative Trait Locus Mapping Under Selective Genotyping

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with ph...

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Detalhes bibliográficos
Main Authors: Manichaikul, Ani, Palmer, Abraham A., Sen, Śaunak, Broman, Karl W.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147971/
https://ncbi.nlm.nih.gov/pubmed/17720902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.080093
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