Prognostic Factors Related to Clinical Response in Patients with Metastatic MelanomaTreated by CTL-Associated Antigen-4 Blockade

PURPOSE: CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade.We have now tr...

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Main Authors: Downey, Stephanie G., Klapper, Jacob A., Smith, Franz O., C.Yang, James, Sherry, Richard M., Royal, Richard E., Kammula, Udai S., Hughes, Marybeth S., Allen, Tamika E., Levy, Catherine L., Michael, Yellin, Nichol, Geoffrey, E.White, Donald, Steinberg, Seth M., Rosenberg, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147083/
https://ncbi.nlm.nih.gov/pubmed/17982122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-0187
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