Prognostic Factors Related to Clinical Response in Patients with Metastatic MelanomaTreated by CTL-Associated Antigen-4 Blockade

PURPOSE: CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade.We have now tr...

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Detalhes bibliográficos
Main Authors: Downey, Stephanie G., Klapper, Jacob A., Smith, Franz O., C.Yang, James, Sherry, Richard M., Royal, Richard E., Kammula, Udai S., Hughes, Marybeth S., Allen, Tamika E., Levy, Catherine L., Michael, Yellin, Nichol, Geoffrey, E.White, Donald, Steinberg, Seth M., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147083/
https://ncbi.nlm.nih.gov/pubmed/17982122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-0187
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