Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands
The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) β(2)-microglobulin-deficient (β(2)m(−/−)) RAG-2(−/−) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to K(b), we identified a single wea...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1998
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.10061 |
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