Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands

The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) β(2)-microglobulin-deficient (β(2)m(−/−)) RAG-2(−/−) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to K(b), we identified a single wea...

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Detalhes bibliográficos
Main Authors: Ghendler, Yoseph, Teng, Mai-kun, Liu, Jin-huan, Witte, Torsten, Liu, Ju, Kim, Ki Seok, Kern, Petra, Chang, Hsiu-Ching, Wang, Jia-huai, Reinherz, Ellis L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21461/
https://ncbi.nlm.nih.gov/pubmed/9707600
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