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Energetic rationale for an unexpected and abrupt reversal of guanidinium chloride-induced unfolding of peptide deformylase

Peptide deformylase (PDF) catalyzes the removal of formyl group from the N-terminal methionine residues of nascent proteins in prokaryotes, and this enzyme is a high priority target for antibiotic design. In pursuit of delineating the structural–functional features of Escherichia coli PDF (EcPDF), w...

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Main Authors: Berg, Alexander K., Manokaran, Sumathra, Eiler, Daniel, Kooren, Joel, Mallik, Sanku, Srivastava, D.K.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144594/
https://ncbi.nlm.nih.gov/pubmed/18042674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073270608
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