Stability and peptide binding specificity of Btk SH2 domain: molecular basis for X-linked agammaglobulinemia.

X-linked agammaglobulinemia (XLA) is caused by mutations in the Bruton's tyrosine kinase (Btk). The absence of functional Btk leads to failure of B-cell development that incapacitates antibody production in XLA patients leading to recurrent bacterial infections. Btk SH2 domain is essential for...

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Main Authors: Tzeng, S. R., Pai, M. T., Lung, F. D., Wu, C. W., Roller, P. P., Lei, B., Wei, C. J., Tu, S. C., Chen, S. H., Soong, W. J., Cheng, J. W.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2000
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144513/
https://ncbi.nlm.nih.gov/pubmed/11206059
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