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Stability and peptide binding specificity of Btk SH2 domain: molecular basis for X-linked agammaglobulinemia.
X-linked agammaglobulinemia (XLA) is caused by mutations in the Bruton's tyrosine kinase (Btk). The absence of functional Btk leads to failure of B-cell development that incapacitates antibody production in XLA patients leading to recurrent bacterial infections. Btk SH2 domain is essential for...
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Päätekijät: | , , , , , , , , , , |
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Aineistotyyppi: | Artigo |
Kieli: | Inglês |
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Cold Spring Harbor Laboratory Press
2000
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2144513/ https://ncbi.nlm.nih.gov/pubmed/11206059 |
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