Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.

Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. We have determined the 2.8-angstroms resolution crystal structure of a truncated, soluble form of recombinant murine CAIV. We have also determined the structure...

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Main Authors: Stams, T., Chen, Y., Boriack-Sjodin, P. A., Hurt, J. D., Liao, J., May, J. A., Dean, T., Laipis, P., Silverman, D. N., Christianson, D. W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143946/
https://ncbi.nlm.nih.gov/pubmed/9541386
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