Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.

One of the major problems encountered in antiviral therapy against AIDS is the emergence of viral variants that exhibit drug resistance. The sequences of proteases (PRs) from related retroviruses sometimes include, at structurally equivalent positions, amino acids identical to those found in drug-re...

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Main Authors: Kervinen, J., Lubkowski, J., Zdanov, A., Bhatt, D., Dunn, B. M., Hui, K. Y., Powell, D. J., Kay, J., Wlodawer, A., Gustchina, A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1998
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143868/
https://ncbi.nlm.nih.gov/pubmed/9827997
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