Characterization of the receptor binding determinants of granulocyte colony stimulating factor.

We performed a series of experiments using alanine-scanning mutagenesis to locate side chains within human granulocyte colony-stimulating factor (G-CSF) that are involved in human G-CSF receptor binding. We constructed a panel of 28 alanine mutants that examined all surface exposed residues on helic...

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Main Authors: Young, D. C., Zhan, H., Cheng, Q. L., Hou, J., Matthews, D. J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143731/
https://ncbi.nlm.nih.gov/pubmed/9194183
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