Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit.

Cholera toxin (CT) produced by Vibrio cholerae and heat-labile enterotoxin (LT-I), produced by enterotoxigenic Escherichia coli, are AB5 heterohexamers with an ADP-ribosylating A subunit and a GM1 receptor binding B pentamer. These toxins are among the most potent mucosal adjuvants known and, hence,...

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Bibliographic Details
Main Authors: van den Akker, F., Feil, I. K., Roach, C., Platas, A. A., Merritt, E. A., Hol, W. G.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143605/
https://ncbi.nlm.nih.gov/pubmed/9416616
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