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Perturbations of the denatured state ensemble: modeling their effects on protein stability and folding kinetics.

By considering the denatured state of a protein as an ensemble of conformations with varying numbers of sequence-specific interactions, the effects on stability, folding kinetics, and aggregation of perturbing these interactions can be predicted from changes in the molecular partition function. From...

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Bibliographic Details
Main Authors: Wrabl, J. O., Shortle, D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1996
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143292/
https://ncbi.nlm.nih.gov/pubmed/8931153
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