Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Cholangiocytes, epithelial cells lining the biliary tree, have primary cilia extending from their apical membrane into the ductal lumen. Although important in disease, cilia also play a vital role in normal cellular functions. We reported that cholangiocyte cilia are sensory organelles responding to...

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Hauptverfasser: Gradilone, Sergio A., Masyuk, Anatoliy I., Splinter, Patrick L., Banales, Jesus M., Huang, Bing Q., Tietz, Pamela S., Masyuk, Tatyana V., LaRusso, Nicholas F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141921/
https://ncbi.nlm.nih.gov/pubmed/18024594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705964104
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