3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis

3-Hydroxyanthranilic acid (HAA), a compound generated during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell death, but its molecular target is not known. Here we report that HAA inhibits NF-κB activation upon T cell antigen receptor engagement by specifical...

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Détails bibliographiques
Auteurs principaux: Hayashi, Tomoko, Mo, Ji-Hun, Gong, Xing, Rossetto, Cyprian, Jang, Angela, Beck, Lucinda, Elliott, Gregory I., Kufareva, Irina, Abagyan, Ruben, Broide, David H., Lee, Jongdae, Raz, Eyal
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141826/
https://ncbi.nlm.nih.gov/pubmed/18003900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709261104
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