Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

Smad4 plays a pivotal role in signal transduction of the transforming growth factor β superfamily cytokines by mediating transcriptional activation of target genes. Hetero-oligomerization of Smad4 with the pathway-restricted SMAD proteins is essential for Smad4-mediated transcription. We provide evi...

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Detalhes bibliográficos
Main Authors: Shioda, Toshi, Lechleider, Robert J., Dunwoodie, Sally L., Li, Huchun, Yahata, Tetsuro, de Caestecker, Mark P., Fenner, Martin H., Roberts, Anita B., Isselbacher, Kurt J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21414/
https://ncbi.nlm.nih.gov/pubmed/9707553
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