Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

Mutations in superoxide dismutase 1 (SOD1), the only proven cause of amyotrophic lateral sclerosis (ALS), provoke disease through an unidentified toxic property. Neurofilament aggregates are pathologic hallmarks of both sporadic and SOD1-mediated familial ALS. By deleting NF-L, the major neurofilame...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Williamson, Toni L., Bruijn, Lucie I., Zhu, Qinzhang, Anderson, Karen L., Anderson, Scott D., Julien, Jean-Pierre, Cleveland, Don W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689132/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9631
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