Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase

To investigate the role of neurofilaments in motor neuron disease caused by superoxide dismutase (SOD1) mutations, transgenic mice expressing a amyotrophic lateral sclerosis-linked SOD1 mutant (SOD1(G37R)) were mated with transgenic mice expressing human neurofilament heavy (NF-H) subunits. Unexpect...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Couillard-Després, Sébastien, Zhu, Qinzhang, Wong, Philip C., Price, Donald L., Cleveland, Don W., Julien, Jean-Pierre
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689131/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9626
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