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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated monocytes and macrophages, and functions as a late mediator of inflammation. Secretion of a nuclear protein requires a tightly contro...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC213771/ https://ncbi.nlm.nih.gov/pubmed/14532127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg516 |
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