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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated monocytes and macrophages, and functions as a late mediator of inflammation. Secretion of a nuclear protein requires a tightly contro...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Bonaldi, Tiziana, Talamo, Fabio, Scaffidi, Paola, Ferrera, Denise, Porto, Annalisa, Bachi, Angela, Rubartelli, Anna, Agresti, Alessandra, Bianchi, Marco E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2003
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Articles
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213771/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14532127/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg516
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