Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression

Obesity causes its complications through functional and morphologic damage to remotely situated tissues via undetermined mechanisms. In one rodent model of obesity, the Zucker diabetic fatty fa/fa rat, overaccumulation of triglycerides in the pancreatic islets may be responsible for a gradual deplet...

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Bibliographic Details
Main Authors: Shimabukuro, Michio, Wang, May-Yun, Zhou, Yan-Ting, Newgard, Christopher B., Unger, Roger H.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21377/
https://ncbi.nlm.nih.gov/pubmed/9689119
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