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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ma, Qing, Jones, Dan, Borghesani, Paul R., Segal, Rosalind A., Nagasawa, Takashi, Kishimoto, Tadamitsu, Bronson, Roderick T., Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21358/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9448
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