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In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

Gross genetic lesions of chromosome 10 occur in 30–50% of sporadic human melanomas. To test the functional significance of this observation, we have developed an in vitro loss of heterozygosity approach in which a wild-type chromosome 10 was transferred into melanoma cells, where there was selection...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Robertson, Gavin P., Furnari, Frank B., Miele, Mary E., Glendening, Michael J., Welch, Danny R., Fountain, Jane W., Lugo, Tracy G., Huang, H.-J. Su, Cavenee, Webster K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21353/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689095/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9418
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