In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

Gross genetic lesions of chromosome 10 occur in 30–50% of sporadic human melanomas. To test the functional significance of this observation, we have developed an in vitro loss of heterozygosity approach in which a wild-type chromosome 10 was transferred into melanoma cells, where there was selection...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Robertson, Gavin P., Furnari, Frank B., Miele, Mary E., Glendening, Michael J., Welch, Danny R., Fountain, Jane W., Lugo, Tracy G., Huang, H.-J. Su, Cavenee, Webster K.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1998
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689095/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9418
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