Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum

Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways. Biosynthesis of LA exclusively occurs in the apicoplast, comprising octanoyl-[acyl carrier...

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Autori principali: Günther, Svenja, Wallace, Lynsey, Patzewitz, Eva-Maria, McMillan, Paul J, Storm, Janet, Wrenger, Carsten, Bissett, Ryan, Smith, Terry K, Müller, Sylke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134950/
https://ncbi.nlm.nih.gov/pubmed/18069893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030189
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