Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

Tuberous sclerosis (TSC) is a familial tumor syndrome due to mutations in TSC1 or TSC2, in which progression to malignancy is rare. Primary Tsc2(–/–) murine embryo fibroblast cultures display early senescence with overexpression of p21(CIP1/WAF1) that is rescued by loss of TP53. Tsc2(–/–)TP53(–/–) c...

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Bibliografiske detaljer
Main Authors: Zhang, Hongbing, Cicchetti, Gregor, Onda, Hiroaki, Koon, Henry B., Asrican, Kirsten, Bajraszewski, Natalia, Vazquez, Francisca, Carpenter, Christopher L., Kwiatkowski, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC213485/
https://ncbi.nlm.nih.gov/pubmed/14561707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317222
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