Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

Receptor tyrosine kinases Flt-1 and Flk-1/KDR, and their ligand, the vascular endothelial growth factor (VEGF), were shown to be essential for angiogenesis in the mouse embryo by gene targeting. Flk-1/KDR null mutant mice exhibited impaired endothelial and hematopoietic cell development. On the othe...

Full description

Saved in:
Bibliographic Details
Main Authors: Hiratsuka, Sachie, Minowa, Osamu, Kuno, Junko, Noda, Tetsuo, Shibuya, Masabumi
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21341/
https://ncbi.nlm.nih.gov/pubmed/9689083
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items