Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

In many malignant cells, both the anchorage requirement for survival and the function of the p53 tumor suppressor gene are subverted. These effects are consistent with the hypothesis that survival signals from extracellular matrix (ECM) suppress a p53-regulated cell death pathway. We report that sur...

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Bibliographic Details
Main Authors: Ilić, Duško, Almeida, Eduardo A.C., Schlaepfer, David D., Dazin, Paul, Aizawa, Shinichi, Damsky, Caroline H.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1998
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132850/
https://ncbi.nlm.nih.gov/pubmed/9786962
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