Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis

Thrombospondin (TSP) 2, and its close relative TSP1, are extracellular proteins whose functions are complex, poorly understood, and controversial. In an attempt to determine the function of TSP2, we disrupted the Thbs2 gene by homologous recombination in embryonic stem cells, and generated TSP2-null...

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Main Authors: Kyriakides, Themis R., Zhu, Yu-Hong, Smith, Lynne T., Bain, Steven D., Yang, Zhantao, Lin, Ming T., Danielson, Keith G., Iozzo, Renato V., LaMarca, Mary, McKinney, Cindy E., Ginns, Edward I., Bornstein, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132586/
https://ncbi.nlm.nih.gov/pubmed/9442117
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