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Implementation of a k/k(0) method to identify long-range structure in transition states during conformational folding/unfolding of proteins

A previously-introduced kinetic-rate constant (k/k(0)) method, where k and k(0) are the folding (unfolding) rate constants in the mutant and the wild-type forms, respectively, of a protein, has been applied to obtain qualitative information about structure in the transition state (TS) ensemble of bo...

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Detalhes bibliográficos
Main Authors: Pradeep, Lovy, Kurinov, Igor, Ealick, Steven E., Scheraga, Harold A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2131734/
https://ncbi.nlm.nih.gov/pubmed/17937908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.08.003
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