A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines

Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in good yield. The reaction mechanism is believed to involve a free-radical sequence resulting in an...

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Bibliographic Details
Main Authors: Russell, Henry F., Bremner, John. B., Bushelle-Edghill, Jennifer, Lewis, Melissa R., Thomas, Stacey R., Bates, Floyd
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2128685/
https://ncbi.nlm.nih.gov/pubmed/18071580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2006.12.136
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