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Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M–G(1) transition in mammals
To investigate the events leading to initiation of DNA replication in mammalian chromosomes, the time when hamster origin recognition complexes (ORCs) became functional was related to the time when Orc1, Orc2 and Mcm3 proteins became stably bound to hamster chromatin. Functional ORCs, defined as tho...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2000
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC212765/ https://ncbi.nlm.nih.gov/pubmed/10835370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.11.2728 |
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