Φορτώνει......
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
We employed Cre/loxP technology to generate mPDK1(–/–) mice, which lack PDK1 in cardiac muscle. Insulin did not activate PKB and S6K, nor did it stimulate 6-phosphofructo-2-kinase and production of fructose 2,6-bisphosphate, in the hearts of mPDK1(–/–) mice, consistent with PDK1 mediating these proc...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2003
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC212735/ https://ncbi.nlm.nih.gov/pubmed/12970179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg469 |
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