Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

We employed Cre/loxP technology to generate mPDK1(–/–) mice, which lack PDK1 in cardiac muscle. Insulin did not activate PKB and S6K, nor did it stimulate 6-phosphofructo-2-kinase and production of fructose 2,6-bisphosphate, in the hearts of mPDK1(–/–) mice, consistent with PDK1 mediating these proc...

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Bibliografiske detaljer
Main Authors: Mora, Alfonso, Davies, Anthony M., Bertrand, Luc, Sharif, Isam, Budas, Grant R., Jovanović, Sofija, Mouton, Véronique, Kahn, C.Ronald, Lucocq, John M., Gray, Gillian A., Jovanović, Aleksandar, Alessi, Dario R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC212735/
https://ncbi.nlm.nih.gov/pubmed/12970179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg469
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