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Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity

We have developed an immunotherapy in which tumor cells transfected with syngeneic major histocompatibility complex (MHC) class II genes are cell-based vaccines for the treatment of established tumor and metastatic disease. If this strategy is to be used clinically, convenient methods for generating...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Armstrong, Todd D., Clements, Virginia K., Martin, Brian K., Ting, Jenny P.-Y., Ostrand-Rosenberg, Suzanne
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21254/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192661/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6886
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