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Evolution subverting essentiality: Dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus

Aphthoviruses use a conserved Arg-Gly-Asp triplet for attachment to host cells and this motif is believed to be essential for virus viability. Here we report that this triplet—which is also a widespread motif involved in cell-to-cell adhesion—can become dispensable upon short-term evolution of the v...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Martínez, Miguel A., Verdaguer, Nuria, Mateu, Mauricio G., Domingo, Esteban
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21238/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192645/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6798
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