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Evolution subverting essentiality: Dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus

Aphthoviruses use a conserved Arg-Gly-Asp triplet for attachment to host cells and this motif is believed to be essential for virus viability. Here we report that this triplet—which is also a widespread motif involved in cell-to-cell adhesion—can become dispensable upon short-term evolution of the v...

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Bibliografische gegevens
Hoofdauteurs: Martínez, Miguel A., Verdaguer, Nuria, Mateu, Mauricio G., Domingo, Esteban
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences of the USA 1997
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21238/
https://ncbi.nlm.nih.gov/pubmed/9192645
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