Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function

The normally dimeric human interleukin 5 (IL-5) was re-engineered into two monomeric isomer forms to investigate mechanistic features of receptor recognition. One form, denoted GM1–IL-5, is a CD-loop expanded form, in which an 8-residue linker designed for flexibility was inserted between residues 8...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Li, Jun, Cook, Richard, Doyle, Michael L., Hensley, Preston, McNulty, Dean E., Chaiken, Irwin
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences of the USA 1997
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC21220/
https://ncbi.nlm.nih.gov/pubmed/9192627
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