Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function

The normally dimeric human interleukin 5 (IL-5) was re-engineered into two monomeric isomer forms to investigate mechanistic features of receptor recognition. One form, denoted GM1–IL-5, is a CD-loop expanded form, in which an 8-residue linker designed for flexibility was inserted between residues 8...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Li, Jun, Cook, Richard, Doyle, Michael L., Hensley, Preston, McNulty, Dean E., Chaiken, Irwin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21220/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6694
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