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Bipartite substrate discrimination by human nucleotide excision repair

Mammalian nucleotide excision repair (NER) eliminates carcinogen–DNA adducts by double endonucleolytic cleavage and subsequent release of 24–32 nucleotide-long single-stranded fragments. Here we manipulated the deoxyribose–phosphate backbone of DNA to analyze the mechanism by which damaged strands a...

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Detalhes bibliográficos
Main Authors: Hess, Martin T., Schwitter, Urs, Petretta, Mario, Giese, Bernd, Naegeli, Hanspeter
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21215/
https://ncbi.nlm.nih.gov/pubmed/9192622
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